WGCNA: In-depth Technical reports
Dept. of Human Genetics, UC Los Angeles
Peter (dot) Langfelder (at) gmail (dot) com,
This page provides technical reports that discuss various features and options
offered by the WGCNA R package. Most of these have not been described in detail in published
Min- vs. mean-denominator TOM
This report explains why using the minimum in the definition of Topological Overlap Measure (TOM)
in weighted networks produces,
in certain special situations, undesirable results, and how the undesirable results are avoided by
replacing the minimum by the average.
This report explains what signed Topological Overlap Measure (TOM) is and why it may be useful in
networks. It also emphasizes that in signed networks
signed TOM is (practically) equal to the standard, unsigned TOM.